A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Efudex Side Effects, and Drug Interactions - Fluorouracil
Efudex Side Effects, and Drug Interactions - Fluorouracil
SIDE EFFECTS
The most frequent adverse reactions to Efudex occur locally
and are often related to an extension of the pharmacological activity of the
drug. These include burning, crusting, allergic contact dermatitis, erosions,
erythema, hyperpigmentation, irritation, pain, photosensitivity, pruritus, scarring,
rash, soreness and ulceration. Ulcerations, other local reactions, cases of
miscarriage and a birth defect (ventricular septal defect) have been reported
when Efudex was applied to mucous membrane areas. Leukocytosis is the most frequent
hematological side effect.
Although a causal relationship is remote, other adverse reactions
which have been reported infrequently are:
Central Nervous System: Emotional upset, insomnia, irritability.
Gastrointestinal: Medicinal taste, stomatitis.
Hematological: Eosinophilia, thrombocytopenia, toxic
granulation.
Integumentary: Alopecia, blistering, bullous pemphigoid,
discomfort, ichthyosis, scaling, suppuration, swelling, telangiectasia, tenderness,
urticaria, skin rash.
Special Senses: Conjunctival reaction, corneal reaction,
lacrimation, nasal irritation. Miscellaneous: Herpes simplex.
DRUG INTERACTIONS
No specific information available.
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