A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Romazicon Online, Description, Chemistry, Ingredients - Flumazenil
Romazicon Online, Description, Chemistry, Ingredients - Flumazenil
ROMAZICON®
(flumazenil)
INJECTION
THE USE OF ROMAZICON HAS BEEN ASSOCIATED WITH THE OCCURRENCE OF SEIZURES.
THESE ARE MOST FREQUENT IN PATIENTS WHO HAVE BEEN ON BENZODIAZEPINES FOR LONG-TERM SEDATION OR IN OVERDOSE CASES WHERE PATIENTS ARE SHOWING SIGNS OF SERIOUS CYCLIC ANTIDEPRESSANT OVERDOSE.
PRACTITIONERS SHOULD INDIVIDUALIZE THE DOSAGE OF ROMAZICON AND BE PREPARED TO MANAGE SEIZURES. |
DESCRIPTION
ROMAZICONÒ
(flumazenil) is a benzodiazepine receptor antagonist. Chemically, flumazenil is ethyl 8-fluoro-5, 6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a](1,4) benzodiazepine-3-carboxylate. Flumazenil has an imidazobenzodiazepine structure, a calculated molecular weight of 303.3, and the following structural formula:
Flumazenil is a white to off-white crystalline compound with
an octanol:buffer partition coefficient of 14 to 1 at pH 7.4. It is insoluble
in water but slightly soluble in acidic aqueous solutions. ROMAZICON is available
as a sterile parenteral dosage form for intravenous administration. Each mL
contains 0.1 mg of flumazenil compoundedwith 1.8 mg of methylparaben, 0.2 mg
of propylparaben, 0.9% sodium chloride, 0.01% edetate disodium, and 0.01% acetic
acid; the pH is adjusted to approximately 4 with hydrochloric acid and/or, if
necessary, sodium hydroxide.
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