A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Fansidar Indications, Dosage, Storage, Stability - Sulfadoxine and Pyrimethamine
Fansidar Indications, Dosage, Storage, Stability - Sulfadoxine and Pyrimethamine
INDICATIONS AND USAGE
Treatment of Acute Malaria
Fansidar is indicated for the treatment of acute, uncomplicated
P. falciparum malaria for those patients in whom chloroquine resistance
is suspected. However, strains of P. falciparum (see CLINICAL
PHARMACOLOGY: Microbiology) may be encountered which have developed
resistance to Fansidar, in which case alternative treatment should be administered.
Prevention of Malaria
Malaria prophylaxis with Fansidar is not routinely recommended
and should only be considered for travelers to areas where chloroquine-resistant
P. falciparum malaria is endemic and sensitive to Fansidar, and when
alternative drugs are not available or are contraindicated (see CONTRAINDICATIONS).
However, strains of P. falciparum may be encountered which have developed
resistance to Fansidar.
DOSAGE AND ADMINISTRATION
(See INDICATIONS AND USAGE)
The dosage should be swallowed whole, and not chewed, with
plenty of fluids after a meal.
|
Treatment of Acute Malaria
|
|
Adults
|
2 to 3 tablets taken as a single dose.
|
| |
|
|
Pediatric patients
|
The dosage for treatment of malaria in
|
|
(>2 months to 18 years)
|
children is based upon body weight:
|
| |
Number of Tablets Taken
|
|
Weight (kg)
|
as a Single Dose
|
|
>45
|
3
|
|
31 to 45
|
2
|
|
21 to 30
|
1 ½
|
|
11 to 20
|
1
|
|
5 to 10
|
½
|
Prevention of Malaria
The malaria risk must be carefully weighed against the risk
of serious adverse drug reactions (see INDICATIONS
AND USAGE). If Fansidar is prescribed for prophylaxis, it is important
that the physician inquires about sulfonamide intolerance and points out
the risk and the need for immediate drug withdrawal if skin reactions
do occur. The first dose of Fansidar should be taken 1 or 2 days before
arrival in an endemic area; administration should be continued during
the stay and for 4 to 6 weeks after return.
| |
|
Once Every
|
|
|
Once Weekly
|
2 Weeks
|
|
Adults
|
1 tablet
|
2 tablets
|
|
Pediatric patients
|
The dosage for prevention of malaria in
|
|
(>2 months to 18 years)
|
children is based upon body weight:
|
| |
|
|
| |
Number of Tablets Taken
|
|
Weight (kg)
|
Once Weekly
|
|
>45
|
1 ½
|
|
31 to 45
|
1
|
|
21 to 30
|
¾
|
|
11 to 20
|
½
|
|
5 to 10
|
¼
|
Prophylaxis with Fansidar should not be continued for more
than two years, since no experience of more prolonged administration is available
to date.
HOW SUPPLIED
Scored tablets, containing 500 mg sulfadoxine and 25 mg pyrimethamine
— unit dose packages of 25 (NDC-0004-0161-03). Imprint on tablets: FANSIDAR
((ROCHE LOGO)) ROCHE.
Manufactured by: F. Hoffmann-La Roche Ltd.
Basel, Switzerland Distributed by:XXXXXXXX , Revised: XXXX XXXX , Copyright
1996-200X by Roche Laboratories Inc. All rights reserved.
Updated Apr 19, 2004
top
