A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Adrenalin Side Effects, and Drug Interactions - Epinephrine / Chlorpheniramine
Adrenalin Side Effects, and Drug Interactions - Epinephrine / Chlorpheniramine
SIDE EFFECTS
EPINEPHRINE
Adverse reactions include transient, moderate anxiety, apprehensiveness,
restlessness, tremor, weakness, dizziness, sweating, palpitations,
pallor, nausea and vomiting, headache, and respiratory difficulties.
These symptoms occur in some persons receiving therapeutic
doses of epinephrine, but are more likely to occur, or to occur
in exaggerated form, in those with hypertension or hyperthyroidism.
Excessive doses cause
acute hypertension. Arrhythmias,
including fatal ventricular
fibrillation, have been reported, particularly in patients with
underlying cardiac disease
or those receiving certain drugs (see DRUG INTERACTIONS
).
Rapid rises in blood
pressure have produced
cerebral hemorrhage, particularly in elderly patients with cerebrovascular
disease. Angina may occur in patients with coronary artery disease.
CHLO-AMINE®
Drowsiness, dizziness, blurred vision, dry mouth
and gastrointestinal upsets may occur. Patients should not drive
or operate machinery
after taking the drug. Large doses produce central
nervous system
depression and occasionally tremors or convulsions. Reports of hematological
disorders are rare.
DRUG INTERACTIONS
Caution is indicated in patients receiving cardiac
glycosides or mercurial diuretics, since these agents may sensitize
the myocardium to
beta-adrenergic stimulation and make cardiac
arrhythmias more likely.
The effects of epinephrine
may be potentiated by tricyclic antidepressants, sodium levothyroxine,
and certain antihistamines, notably chlorpheniramine, tripelennamine,
and diphenhydramine. The cardiostimulating and bronchodilating effects
of epinephrine are
antagonized by beta-adrenergic blocking
drugs, such as propranolol. The vasoconstricting and hypertensive
effects are antagonized by alpha-adrenergic blocking
drugs, such as phentolamine. Ergot alkaloids and phenothiazines
may also reverse the pressor
effects of epinephrine.
Diabetic patients receiving epinephrine
may require an increased dose of insulin
or oral hypoglycemic drugs.
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