A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Adrenalin Side Effects, and Drug Interactions - Epinephrine
Adrenalin Side Effects, and Drug Interactions - Epinephrine
SIDE EFFECTS
Transient and minor side
effects of anxiety, headache, fear
and palpitations occur with systemic
therapeutic doses,
especially in hyperthyroid individuals. Adverse effects such as
cardiac arrhythmias
and excessive rise in blood pressure may also occur with therapeutic
doses or inadvertent overdosage. Other adverse reactions include
cerebral hemorrhage, hemiplegia, subarachnoid hemorrhage, anginal
pain in patients with angina
pectoris, anxiety, restlessness, throbbing headache, tremor, weakness
dizziness, pallor and
respiratory difficulty.
DRUG INTERACTIONS
Epinephrine should be used cautiously in patients with hyperthyroidism,
hypertension and cardiac
arrhythmias. All vasopressors should be used cautiously in patients
taking monoamine oxidase
(MAO) inhibitors.
Epinephrine should not be administered concomitantly with other
sympathomimetic drugs (such as isoproterenol) because of possible
additive effects and
increased toxicity.
Combined effects may induce serious cardiac
arrhythmias. They may be administered alternately when the preceding
effect of other such
drug has subsided.
Administration of epinephrine
to patients receiving cyclopropane
or halogenated hydrocarbon
general anesthetics such as halothane
which sensitize the myocardium, may induce cardiac
arrhythmia. (See CONTRAINDICATIONS).
When encountered, such arrhythmias may respond to administration
of a beta-adrenergic blocking drug. Epinephrine also should be used
cautiously with other drugs (e.g., digitalis, glycosides) that sensitize
the myocardium to
the actions of sympathomimetic
drugs.
Diuretic agents may decrease vascular
response to pressor
drugs such as epinephrine.
Epinephrine may antagonize the neuron
blockade produced by
guanethidine resulting in decreased antihypertensive
effect and requiring
increased dosage of the latter.
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