Emend Online, Description, Chemistry, Ingredients - Aprepitant

Emend Online, Description, Chemistry, Ingredients - Aprepitant

EMEND@ (aprepitant) CAPSULES

EMEND* (aprepitant) is a substance Plneurokinin 1 (NK1) receptor antagonist, chemically described as 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4- morpholinyl]methyl]-1,2-dihydro-3H-l,2,4-triazol-3-one.

Its empirical formula is C₂₃H₂₁F₇N₄O_3.

Aprepitant is a white to off-white crystalline solid, with a molecular weight of 534.43. It is practically insoluble in water. Aprepitant is sparingly soluble in ethanol and isopropyl acetate and slightly soluble in acetonitrile.

Each capsule of EMEND for oral administration contains either 80 mg or 125 mg of aprepitant and the following inactive ingredients: sucrose, microcrystalline cellulose, hydroxypropyl cellulose and sodium lauryl sulfate. The capsule shell excipients are gelatin and titanium dioxide. The 125-mg capsule also contains red ferric oxide and yellow ferric oxide.