A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Enlon Side Effects, and Drug Interactions - Edrophonium (injection)
Enlon Side Effects, and Drug Interactions - Edrophonium (injection)
SIDE EFFECTS
Careful observation should be made for severe cholinergic reactions in
the hyperreactive individual. The myasthenic patient in crisis who is
being tested with Enlon® should be observed for bradycardia
or cardiac standstill and cholinergic reactions if an overdose is given.
The following reactions common to anticholinesterase agents may occur,
although not all of these reactions have been reported with the administration
of Enlon®, probably because of its short duration of action
and limited indications:
| Eye: |
|
Increased lacrimation, pupillary constriction, spasm of accommodation,
diplopia, conjunctival hyperemia.
|
| CNS: |
|
Convulsions, dysarthria, dysphonia, dysphagia. |
| Respiratory: |
|
Increased tracheobronchial secretions, laryngospasm, bronchiolar
constriction, paralysis of muscles of respiration, central respiratory
paralysis.
|
| Cardiac: |
|
Arrhythmias (especially bradycardia), fall in cardiac output leading
to hypotension. Increased salivary, gastric and intestinal secretion,
nausea, vomiting, increased peristalsis, diarrhea, abdominal cramps.
|
| Skeletal Muscle: |
|
Weakness, fasciculations. |
| Miscellaneous: |
|
Increased urinary frequency and incontinence, diaphoresis. |
DRUG INTERACTIONS
Care should be given when administering this drug to patients with symptoms
of myasthenic weakness who are also on anticholinesterase drugs. Since
symptoms of anticholinesterase overdose (cholinergic crisis) may mimic
underdosage (myasthenic weakness), their condition may be worsened by
the use of this drug. (See OVERDOSAGE
section for treatment.)
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