A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Edecrin Pharmacology, Pharmacokinetics, Studies, Metabolism - Ethacrynic Acid
Edecrin Pharmacology, Pharmacokinetics, Studies, Metabolism - Ethacrynic Acid
CLINICAL PHARMACOLOGY
Pharmacokinetics and Metabolism
EDECRIN acts on the ascending limb
of the loop of Henle and
on the proximal and distal
tubules. Urinary output
is usually dose dependent
and related to the magnitude
of fluid accumulation.
Water and electrolyte
excretion may be increased several times over that observed with
thiazide diuretics, since EDECRIN inhibits reabsorption
of a much greater proportion of filtered sodium than most other
diuretic agents. Therefore,
EDECRIN is effective in many patients who have significant
degrees of renal insufficiency
(see WARNINGS concerning
deafness). EDECRIN has little or no effect
on glomerular filtration
or on renal blood
flow, except following pronounced reductions in plasma
volume when associated
with rapid diuresis.
The electrolyte
excretion pattern
of ethacrynic acid varies
from that of the thiazides and mercurial
diuretics. Initial sodium
and chloride excretion
is usually substantial and chloride
loss exceeds that of sodium.
With prolonged administration, chloride
excretion declines,
and potassium and
hydrogen ion excretion
may increase. EDECRIN is effective whether or not there is clinical
acidosis or alkalosis.
Although EDECRIN, in carefully controlled studies in animals and
experimental subjects, produces a more favorable sodium
/ potassium excretion
ratio than the thiazides, in patients with increased diuresis
excessive amounts of potassium
may be excreted.
Onset of action is rapid,
usually within 30 minutes after an oral
dose of EDECRIN or within 5 minutes after an intravenous
injection of SODIUM
EDECRIN. After oral use,
diuresis peaks in about
2 hours and lasts about 6 to 8 hours.
The sulfhydryl binding
propensity of ethacrynic acid
differs somewhat from that of the organomercurials. Its mode
of action is not by carbonic
anhydrase inhibition.
Ethacrynic acid does not
cross the blood- brain
barrier.
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