A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Edecrin Online, Description, Chemistry, Ingredients - Ethacrynic Acid
Edecrin Online, Description, Chemistry, Ingredients - Ethacrynic Acid
DESCRIPTION
| EDECRIN* (Ethacrynic Acid) is a potent
diuretic which,
if given in excessive amounts, may lead
to profound diuresis
with water and electrolyte
depletion. Therefore, careful medical
supervision is required, and dose and dose
schedule must
be adjusted to the individual patient’s needs (see DOSAGE
AND ADMINISTRATION). |
TABLETS
EDECRIN® (ETHACRYNIC ACID)
and INTRAVENOUS
SODIUM EDECRIN® (ETHACRYNATE SODIUM)
Ethacrynic acid is an
unsaturated ketone
derivative of an
aryloxyacetic acid. It is designated chemically as [2,3-dichloro-4-(2-
methylene-1-oxobutyl) phenoxyl acetic
acid, and has a molecular weight
of 303.14. Ethacrynic acid is a white, or practically white, crystalline
powder, very slightly soluble in water, but soluble
in most organic solvents
such as alcohols, chloroform, and benzene. Its empirical
formula is C13H12C12O4
.
Ethacrynate sodium, the sodium
salt of ethacrynic acid,
is soluble in water
at 25° C to the extent of about 7 percent. Solutions of the
sodium salt are relatively stable
at about pH 7 at room
temperature for
short periods, but as the pH
or temperature increases
the solutions are less stable. The molecular weight
of ethacrynate sodium
is 325.12. Its empirical formula is C13H11C12NaO4
.
EDECRIN is supplied as 25 mg
and 50 mg tablets for oral
use. Each tablet contains the following inactive ingredients: colloidal
silicon dioxide, lactose,
magnesium stearate,
starch and talc. The
50 mg tablet
also contains D& C Yellow 10, FD& C Blue 1 and FD& C
Yellow 6. Intravenous SODIUM EDECRIN* (Ethacrynate Sodium) is a
sterile freeze-dried
powder and is supplied
in a vial containing:
Ethacrynate sodium equivalent
to ethacrynic acid 50.0
mg
Inactive ingredients: Mannitol 62.5 mg
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