A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Inapsine Side Effects, and Drug Interactions - Droperidol
Inapsine Side Effects, and Drug Interactions - Droperidol
SIDE EFFECTS
The most common somatic
adverse reactions reported to occur with INAPSINE (droperidol) are
mild to moderate hypotension
and tachycardia,
but these effects usually subside without treatment. If hypotension
occurs and is severe or persists, the possibility of hypovolemia
should be considered and managed with appropriate
parenteral fluid
therapy.
The most common behavioral adverse effects of INAPSINE (droperidol)
include dyspheria, postoperative drowsiness,
rest- lessness, hyperactivity and anxiety,
which can either be the result of an inadequate dosage
(lack of adequate treatment
effect) or of an adverse drug
reaction (part of the
symptom complex of akathisia).
Care should be taken to search for extrapyramidal
signs and symptoms (dystonia, akathisia,
oculogyric crisis)
to differentiate these different clinical conditions. When extrapyramidal
symptoms are the cause, they can usually be controlled with anticholinergic
agents.
Postoperative hallucinatory episodes (sometimes associated with
transient periods of mental
depression) have also been reported.
Other less common reported adverse reactions include anaphylaxis,
dizziness, chills and
or shivering, laryngospasm, and bronchospasm.
Elevated blood pressure
with or without pre-existing hypertension
has been reported following administration
of INAPSINE combined with SUBLIMAZE (fentanyl citrate) or other
parenteral analgesics.
This might be due to unexplained alterations in sympathetic
activity following
large doses; however, it is also frequently attributed to anesthetic
or surgical stimulation
during light anesthesia.
DRUG INTERACTIONS
Other CNS depressant
drugs (e.g. barbiturates, tranquilizers, opioids and general anesthetics)
have additive or potentiating
effects with INAPSINE. When patients have received such
drugs, the dose of INAPSINE
required will be less than usual. Following the administration
of INAPSINE, the dose of other CNS
depressant drugs
should be reduced.
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