A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Dopamine Side Effects, and Drug Interactions - Dopamine
Dopamine Side Effects, and Drug Interactions - Dopamine
SIDE EFFECTS
The following adverse reactions have been observed, but there are
not enough data to support
an estimate of their frequency.
Cardiovascular System:
ventricular arrhythmia
(at very high doses)
ectopic beats
tachycardia
anginal pain
palpitation
cardiac conduction
abnormalities
widened QRS complex
bradycardia
hypotension
hypertension
vasoconstriction
Respiratory System:
Gastrointestinal System:
Metabolic/Nutritional System:
Central Nervous System:
Dermatological System:
Other:
Gangrene of the extremities has occurred when high doses were administered
for prolonged periods or in patients with occlusive
vascular disease
receiving low doses of dopamine HCl.
DRUG INTERACTIONS
Because dopamine is metabolized by monoamine
oxidase (MAO), inhibition
of this enzyme prolongs
and potentiates the effect
of dopamine. Patients who have been treated with MAO inhibitors
within two to three weeks prior to the administration
of dopamine HCl should receive initial
doses of dopamine HCl no greater than one-tenth (1/10) of the usual
dose.
Concurrent administration
of dopamine HCl and diuretic agents may produce an additive
or potentiating effect
on urine flow.
Tricyclic antidepressants may potentiate
the pressor response
to adrenergic agents.
Cardiac effects of dopamine are antagonized by beta-adrenergic
blocking agents, such as propranolol and metoprolol. The peripheral
vasoconstriction caused by high doses of dopamine HCl is antagonized
by alpha-adrenergic blocking agents. Dopamine-induced renal
and mesenteric vasodilation
is not antagonized by either alpha-or beta-adrenergic blocking
agents.
Haloperidol appears to have strong central
antidopaminergic properties. Haloperidol and haloperidol-like drugs
suppress the dopaminergic
renal and mesenteric vasodilation
induced at low rates
of dopamine infusion.
Cyclopropane or halogenated hydrocarbon
anesthetics increase cardiac autonomic
irritability and may sensitize the myocardium
to the action of certain intravenously administered catecholamines,
such as dopamine. This interaction appears to be related both to
pressor activity and
to beta-adrenergic stimulating properties of these catecholamines
and may produce ventricular
arrhythmias and hypertension. Therefore, EXTREME CAUTION should
be exercised when administering dopamine HCl to patients receiving
cyclopropane or halogenated hydrocarbon
anesthetics. It has been reported that results of studies in animals
indicate that dopamine-induced ventricular arrhythmias during anesthesia
can be reversed by propranolol.
The concomitant
use of vasopressors and some oxytocic drugs may result in
severe persistent hypertension. See PRECAUTIONS:
Labor and Delivery.
Administration of phenytoin
to patients receiving dopamine HCl has been reported to lead
to hypotension and
bradycardia. It is suggested that in patients receiving dopamine
HCl, alternatives to phenytoin
should be used if anticonvulsant
therapy is needed.
top
