A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Taxotere Overdose, Contraindications and Information - Docetaxel
Taxotere Overdose, Contraindications and Information - Docetaxel
OVERDOSE
There is no known antidote for TAXOTERE overdosage. In case
of overdosage, the patient should be kept in a specialized unit where vital
functions can be closely monitored. Anticipated complications of overdosage
include: bone marrow suppression, peripheral neurotoxi-city, and mucositis.
Patients should receive therapeutic G-CSF as soon as possible after discovery
of overdose. Other appropriate symptomatic measures should be taken, as needed.
In two reports of overdose, one patient received 150 mg/m2
and the other received 200 mg/m2 as 1-hour infusions. Both
patients experienced severe neutropenia, mild asthenia, cutaneous reactions,
and mild paresthesia, and recovered without incident.
In mice, lethality was observed following single IV doses that
were >154 mg/kg (about 4.5 times the recommended human dose on a mg/m2
basis); neurotoxicity associated with paralysis, non-extension of hind
limbs, and myelin degeneration was observed in mice at 48 mg/kg (about 1.5 times
the recommended human dose on a mg/m2 basis). In male and female
rats, lethality was observed at a dose of 20 mg/kg (comparable to the recommended
human dose on a mg/m2 basis) and was associated with abnormal mitosis
and necrosis of multiple organs.
CONTRAINDICATIONS
TAXOTERE is contraindicated in patients who have a history
of severe hypersensitivity reactions to docetaxel or to other drugs formulated
with polysorbate 80.
TAXOTERE should not be used in patients with neutrophil counts
of <1500 cells/mm3.
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