A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Benadryl Warnings, Precautions, Pregnancy, Nursing, Abuse - Diphenhydramine (injection)
Benadryl Warnings, Precautions, Pregnancy, Nursing, Abuse - Diphenhydramine (injection)
WARNINGS
Antihistamines should be used with considerable caution in patients
with narrow-angle glaucoma,
stenosing peptic ulcer,
pyloroduodenal obstruction, symptomatic prostatic
hypertrophy, or
bladder-neck obstruction.
Local necrosis has
been associated with the use of subcutaneous
or intradermal use of intravenous
Benadryl.
Use in Pediatric Patients
In pediatric patients,
especially, antihistamines in overdosage may cause hallucinations,
convulsions, or death.
As in adults, antihistamines may diminish mental
alertness in pediatric patients. In
the young pediatric
patient, particularly,
they may produce excitation.
Use in the Elderly (approximately 60 years or older)
Antihistamines are more likely to cause
dizziness, sedation,
and hypotension in elderly patients.
PRECAUTIONS
General
Diphenhydramine hydrochloride
has an atropine-like action
and therefore, should
be used with caution in patients with a history
of bronchial asthma,
increased intraocular
pressure, hyperthyroidism,
cardiovascular
disease or hypertension. Use with caution in patients with lower
respiratory disease
including asthma.
Information for Patients
Patients taking diphenhydramine hydrochloride
should be advised that this drug
may cause drowsiness
and has an additive
effect with alcohol.
Patients should be warned about engaging in activities requiring
mental alertness such as
driving a car or operating appliances, machinery, etc..
Drug Interactions
Diphenhydramine hydrochloride
has additive effects
with alcohol and other
CNS depressants (hypnotics,
sedatives, tranquilizers, etc).
MAO inhibitors prolong and intensify the anticholinergic
(drying) effects of antihistamines.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term studies in animals to determine mutagenic and carcinogenic
potential have not been performed.
Pregnancy
Pregnancy Category B. Reproduction studies have been
performed in rats and rabbits at doses up to 5 times the human
dose and have revealed
no evidence of impaired
fertility or harm
to the fetus due to diphenhydramine
hydrochloride. There are, however, no
adequate and well-controlled studies in pregnant
women. Because animal
reproduction studies
are not always predictive of human
response, this drug should
be used during pregnancy
only if clearly needed.
Pediatric Use
Benadryl should not be used in neonates and premature
infants (see CONTRAINDICATIONS).
Benadryl may diminish mental
alertness, or, in the young pediatric
patient, cause excitation. Overdosage may cause
hallucinations, convulsions, or death (see WARNINGS
,
OVERDOSAGE, and DOSAGE
AND ADMINISTRATION sections).
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