A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tenuate Overdose, Contraindications and Information - Diethylpropion
Tenuate Overdose, Contraindications and Information - Diethylpropion
OVERDOSE
Manifestations of acute
overdosage include restlessness, tremor,
hyperreflexia, rapid respiration,
confusion, assaultiveness,
hallucinations, panic
states.
Fatigue and depression
usually follow the central
stimulation. Cardiovascular effects include arrhythmias, hypertension
or hypotension and
circulatory collapse. Gastrointestinal symptoms include nausea,
vomiting, diarrhea,
and abdominal cramps.
Overdose of pharmacologically similar compounds has resulted in
convulsions, coma and death.
The reported oral LD50
for mice is 600 mg/ kg, for rats is 250 mg/kg and for dogs is 225
mg/kg.
Management of acute diethylpropion
hydrochloride
intoxication is
largely symptomatic and includes lavage
and sedation with a
barbiturate. Experience with hemodialysis
or peritoneal dialysis
is inadequate to permit recommendation in this regard. Intravenous
phentolamine (Regitine®) has been suggested on pharmacologic
grounds for possible acute,
severe hypertension,
if this complicates TENUATE or TENUATE DOSPAN overdosage.
CONTRAINDICATIONS
Advanced arteriosclerosis, hyperthyroidism,
known hypersensitivity
or idiosyncrasy to the sympathomimetic
amines, glaucoma, severe
hypertension. (See PRECAUTIONS.)
Agitated states.
Patients with a history
of drug abuse.
During or within 14 days following the administration
of monoamine oxidase
inhibitors, hypertensive
crises may result.
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