A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tenuate Side Effects, and Drug Interactions - Diethylpropion
Tenuate Side Effects, and Drug Interactions - Diethylpropion
SIDE EFFECTS
Cardiovascular: Precordial pain,
arrhythmia, ECG
changes, tachycardia, elevation
of blood pressure,
palpitation
Central Nervous System: In
a few epileptics an increase in convulsive
episodes has been reported; rarely psychotic
episodes at recommended doses; dyskinesia,
blurred vision, overstimulation, nervousness, restlessness, dizziness,
jitteriness, insomnia,
anxiety, euphoria,
depression, dysphoria, tremor,
mydriasis, drowsiness,
malaise, headache
Gastrointestinal: Vomiting, diarrhea,
abdominal discomfort,
dryness of the mouth,
unpleasant taste, nausea,
constipation, other
gastrointestinal disturbances
Allergic: Urticaria, rash,
ecchymosis, erythema
Endocrine: Impotence, changes in libido,
gynecomastia, menstrual upset
Hematopoletic System: Bone marrow
depression, agranulocytosis,
leukopenia
Miscellaneous: A variety
of miscellaneous adverse reactions has been reported by physicians.
These include complaints such
as dysuria, dyspnea, hair
loss, muscle pain,
increased sweating, and polyuria.
DRUG ABUSE AND DEPENDENCE
TENUATE and TENUATE DOSPAN are schedule
IV controlled substances.
Diethylpropion hydrochloride has some chemical
and pharmacologic similarities to the amphetamines and other related
stimulant drugs that
have been extensively abused. There have been reports of subjects
becoming psychologically dependent on diethylpropion. The possibility
of abuse should be kept
in mind when evaluating
the desirability of including a drug
as proof of a weight
reduction program.
Abuse of amphetamines and related drugs may be associated with varying
degrees of psychologic dependence and social dysfunction
which, in the case of certain
drugs, may be severe. There are reports of patients who have increased
the dosage to many times that recommended. Abrupt cessation following
prolonged high dosage administration
results in extreme fatigue
and mental depression;
changes are also noted on the sleep
EEG.
Manifestations of chronic
intoxication with
anorectic drugs include
severe dermatoses, marked insomnia,
irritability, hyperactivity, and personality changes. The most severe
manifestation
of chronic intoxication
is psychosis, often clinically indistinguishable from schizophrenia.
DRUG INTERACTIONS
Antidiabetic drug requirements
(i.e., insulin) may be altered. Concurrent use with general anesthetics
may result in arrhythmias. The pressor
effects of diethylpropion and those of other drugs may be additive
when the drugs are used concomitantly; conversely, diethylpropion
may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa).
Concurrent use of phenothiazines
may antagonize the anorectic
effect of diethylpropion.
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