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Dexone Side Effects, and Drug Interactions - Dexamethasone
SIDE EFFECTS
Fluid and Electrolyte Disturbances: Sodium retention; Fluid retention; Congestive heart failure in susceptible patients: Potassium loss; Hypokalemic alkalosis & Hypertension.
Musculoskeletal: Muscle weakness; Steroid myopathy; Loss of muscle mass; Osteoporosis; Vertebral compression fractures; Aseptic necrosis of femoral and humeral heads; Pathologic fracture of long bones & Tendon rupture.
Gastrointestinal: Peptic ulcer with possible perforation and hemorrhage. Perforation of the small and large bowel; particularly in patients with inflammatory bowel disease; Pancreatitis; Abdominal distention & Ulcerative esophagitis.
Dermatologic: Impaired wound healing; Thin fragile skin; Petechiae and ecchymoses; Erythema, increased sweating, may suppress reactions to skin tests. Other cutaneous reactions; such as allergic dermatitis, urticaria; angioneurotic edema.
Neurologic: Convulsions; Increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment, Vertigo & Headache.
Endocrine: Menstrual irregularities; Development of Cushingoid state; Suppression of growth in children; Secondary adrenocortical and pituitary unresponsiveness; particularly in times of stress; as in trauma; surgery; or illness; Decreased carbohydrate tolerance; Manifestations of latent diabetes mellitus; Increased requirements for insulin or oral hypoglycemic agents in diabetes & Hirsutism.
Ophthalmic: Posterior subcapsular cataracts; increased intraocular pressure; Glaucoma & Exophthalmos.
Metabolic: Negative nitrogen balance due to protein catabolism.
Other: Hypersensitivity; Thromboembolism; Weight gain; Increased
appetite; Nausea; Malaise.
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