A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Declomycin Indications, Dosage, Storage, Stability - Demeclocycline HCl
Declomycin Indications, Dosage, Storage, Stability - Demeclocycline HCl
INDICATIONS
DECLOMYCIN demeclocycline hydrochloride is indicated in infections caused
by the following microorganisms:
- Rickettsiae: (Rocky Mountain spotted fever, typhus fever and
the typhus group, Q fever, rickettsial pox, tick fevers).
- Mycoplasma pneumoniae (PPLO, Eaton agent).
- Agents of psittacosis and ornithosis.
- Agents of lymphogranulomavenereum and granuloma inguinale.
- The spirochetal agent of relapsing fever (Borrelia recurrentis).
The following gram-negative microorganisms:
- Haemophilus ducreyi (chancroid),
- Yersinia pestis and Francisella tolarensis, formerly
- Pasteurella pestis and Pasteurella tularensis, Bartonella bacilliformis,
- Bacteroides species,
- Vibrio comma and Vibrio fetus,
- Brucella species (in conjunction with streptomycin).
Because many strains of the following groups of microorganisms have been
shown to be resistant to tetracyclines, culture and susceptibility testing
are recommended.
Demeclocycline is indicated for treatment of infections caused by the
following gram-negative microorganisms, when bacteriologic testing indicates
appropriate susceptibility to the drug:
- Escherichia coli,
- Enterobacter aerogenex (formerly Aerobacter aerogenes),
- Shigella species,
- Mima species and Herellea species,
- Haemophilus influenzae (respiratory infections),
- Klebsiella species (respiratory and urinary infections).
DECLOMYCIN is indicated for treatment of infections caused by the following
gram-positive microorganisms when bacteriologic testing indicates appropriate
susceptibility to the dnug:
Up to 44% of strains of Streptococcus pyogenes and 74% of Streptococcus
faecalis have been found to be resistant to tetracycline drugs. Therefore,
tetracyclines should not be used for streptococcal disease unless the
organism has been demonstrated to be sensitive.
For upper respiratory infections due to Group A beta-hemolytic streptococci,
penicillin is the usual drug of choice, including prophylaxis of rheumatic
fever.
- Streptococcus pneumoniae,
- Staphylococcus aureus, skin and soft tissue infections.
Tetracyclines are not the drugs of choice in the treatment of any type
of staphylococcal infection.
When penicillin is contraindicated, tetracyclines are alternative drugs
in the treatment of infections due to:
- Neisseria gonorrhoeae,
- Treponema pallidum and Treponema pertenue (syphilis
and yaws),
- Listeria monocytogenes,
- Clostridium species,
- Bacillus anthracis,
- Fusobacterium fusiforme (Vincent’s infection),
- Actinomyces species.
In acute intestinal amebiasis, the tetracyclines may be a useful adjunct
to amebicidon.
DECLOMYCIN demeclocycline hydrochloride is indicated in the treatment
of trachoma, although the infectious agent is not always eliminated, as
judged by immunofluorescence.
Inclusion conjunctivitis may be treated with oral tetracyclines or with
a combination of oral and topical agents.
DOSAGE AND ADMINISTRATION
Therapy should be continued for at least 24 to 48 hours after symptoms
and fever have subsided.
Concomitant therapy: Antacids containing aluminum, calcium, or magnesium
impair absorption and should not be given to patients taking oral tetracycline.
Foods and some dairy products also interfere with absorption. Oral forms
of tetracycline should be given one hour before or two hours after meals.
In patients with renal impairment (See WARNINGS.)
total dosage should be decreased by reduction of recommended individual
doses and/or by extending time intervals between doses.
In the treatment of streptococcal infections, a therapeutic dose of demeclocycline
should be administered for at least ten days
Adults: Usual daily dose, Four divided doses of 150 mg each or two divided
doses of 300 mg
For children above eight years of age: Usual daily dose, 3-6 mg per pound
body weight per day, depending upon the severity of the disease, divided
into two to four doses.
Gonorrhea patients sensitive to penicillin may be treated with demeclocycline
administered as an initial oral dose of 600 mg followed by 300 mg every
12 hours for four days to a total of 3 grams.
HOW SUPPLIED
DECLOMYCIN demeclocycline hydrochloride Tablets, 150 mg are round, convex,
red, film coated tablets, engraved with LL on one side and D11 on the
other, are supplied as follows:
NDC 0005-9218-23
- Bottle of 100
DECLOMYCIN demeclocycline hydrochloride Tablets, 300 mg are round, convex,
red, film coated tablets, engraved with LL on one side and D12 on the
other, are supplied as follows
NDC 0005-9270-29
- Bottle of 48
Store at controlled room temperature 20°- 25° C (68°- 77° F).
top
