A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Delatestryl Side Effects, and Drug Interactions - Testosterone Enanthate
Delatestryl Side Effects, and Drug Interactions - Testosterone Enanthate
SIDE EFFECTS
Endocrine and Urogenital, Female: The most common
side effects of androgen
therapy are amenorrhea
and other menstrual irregularities, inhibition of gonadotropin
secretion, and virilization,
including deepening of the voice
and clitoral enlargement. The latter usually is not reversible after
androgens are discontinued. When administered to a pregnant
woman, androgens cause
virilization of
the external genitalia
of the female fetus.
Male: Gynecomastia, and excessive frequency
and duration of penile
erections. Oligospermia may occur at high dosages (see CLINICAL
PHARMACOLOGY).
Skin and Appendages: Hirsutism, male
pattern baldness, and
acne.
Fluid and Electrolyte Disturbances: Retention of
sodium, chloride, water, potassium,
calcium (see WARNINGS),
and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice,
alterations in liver function
tests; rarely, hepatocellular
neoplasms, peliosis
hepatis (see WARNINGS).
Hematologic: Suppression of clotting
factors Il, V, VII, and X; bleeding
in patients on concomitant
anticoagulant
therapy; polycythemia.
Nervous System: Increased or decreased libido,
headache, anxiety, depression,
and generalized paresthesia.
Metabolic: Increased serum
cholesterol.
Miscellaneous: Rarely, anaphylactoid reactions; inflammation
and pain at injection
site.
DRUG ABUSE AND DEPENDENCE
DELATESTRYL is classified as a controlled substance
under the Anabolic Steroids Control Act of 1990 and has been assigned
to Schedule III.
DRUG INTERACTIONS
When administered concurrently, the following drugs may interact
with androgens:
Anticoagulants, oral: C-17 substituted derivatives
of testosterone, such as
methandrostenolone, have been reported to decrease the anticoagulant
requirement. Patients receiving oral
anticoagulant
therapy require close monitoring especially when androgens are started
or stopped.
Antidiabetic drugs and insulin: In
diabetic patients,
the metabolic effects of androgens may decrease blood
glucose and insulin
requirements.
ACTH and corticosteroids: Enhanced tendency toward
edema. Use caution when giving these drugs together, especially
in patients with hepatic or cardiac
disease.
Oxyphenbutazone: Elevated serum
levels of oxyphen butazone may result.
Drug/ Laboratory Test Interferences
Androgens may decrease levels of thyroxine-binding globulin, resulting
in decreased total T4 serum
1evels and increased resin
uptake of T3 and T4. Free thyroid
hormone levels remain
unchanged, however, and there is no
clinical evidence
of thyroid dysfunction.
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