A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Santyl Warnings, Precautions, Pregnancy, Nursing, Abuse - Collagenase
Santyl Warnings, Precautions, Pregnancy, Nursing, Abuse - Collagenase
WARNINGS
No information provided
PRECAUTIONS
The optimal pH range of collagenase is 6 to 8. Higher or lower pH conditions
will decrease the enzyme's activity and appropriate precautions should
be taken. The enzymatic activity is also adversely affected by certain
detergents, and heavy metal ions such as mercury and silver which are
used in some antiseptics. When it is suspected such materials have been
used, the site should be carefully cleansed by repeated washings with
normal saline before Collagenase Santyl® Ointment is applied.
Soaks containing metal ions or acidic solutions should be avoided because
of the metal ion and low pH. Cleansing materials such as hydrogen peroxide,
Dakin's solution, and normal saline are compatible with Collagenase Santyl®
Ointment.
Debilitated patients should be closely monitored for systemic bacterial
infections because of the theoretical possibility that debriding enzymes
may increase the risk of bacteremia.
A slight transient erythema has been noted occasionally in the surrounding
tissue, particularly when Collagenase Santyl® Ointment
was not confined to the wound. Therefore, the ointment should be applied
carefully within the area of the wound. Safety and effectiveness in pediatric
patients have not been established.
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