Codeine Pharmacology, Pharmacokinetics, Studies, Metabolism - Codeine

Codeine Pharmacology, Pharmacokinetics, Studies, Metabolism - Codeine

CLINICAL PHARMACOLOGY

The major effects of codeine are on the central nervous system and the bowel. Opioids act as agonists, interacting with stereospecific and saturable binding sites or receptors in the brain and other tissues.

Codeine is readily absorbed from the gastrointestinal tract with the maximum analgesic effect occurring 60 minutes post administration. Codeine retains at least one half its analgesic activity when administered orally.