A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Lamprene Side Effects, and Drug Interactions - Clofazimine
Lamprene Side Effects, and Drug Interactions - Clofazimine
SIDE EFFECTS
In general, Lamprene is well tolerated when administered in dosages no
greater than 100 mg daily. The most consistent adverse reactions are usually
dose related and are usually reversible when Lamprene is discontinued.
Adverse Reactions Occurring In More Than 1% of Patients
Skin: Pigmentation from pink to brownish-black in 75%-100%
of the patients within a few weeks of treatment; ichthyosis and dryness
(8%-28%); rash and pruritus (1%-5%).
Gastrointestinal: Abdominal and epigastric pain, diarrhea,
nausea, vomiting, gastrointestinal intolerance (40%-50%).
Ocular: Conjunctival and corneal pigmentation due to clofazimine
crystal deposits; dryness; burning; itching; irritation.
Other: Discoloration of urine, feces, sputum, sweat; elevated
blood sugar; elevated ESR.
Adverse Reactions Occurring In Less Than 1% of Patients
Skin: Phototoxicity, erythroderma, acneiform eruptions,
monilial cheilosis.
Gastrointestinal: Bowel obstruction (see WARNINGS),
gastrointestinal bleeding (see WARNINGS),
anorexia, constipation, weight loss, hepatitis, jaundice, eosinophilic
enteritis, enlarged liver.
Ocular: Diminished vision.
Nervous: Dizziness, drowsiness, fatigue, headache, giddiness,
neuralgia, taste disorder.
Psychiatric: Depression secondary to skin discoloration;
two suicides have been reported.
Laboratory: Elevated levels of albumin, serum bilirubin,
and AST (SGOT); eosinophilia; hypokalemia.
Other: Splenic infarction (see WARNINGS),
thromboembolism, anemia, cystitis, bone pain, edema, fever, lymphadenopathy,
vascular pain.
DRUG INTERACTIONS
Preliminary data which suggest that dapsone may inhibit the anti-inflammatory
activity of Lamprene have not been confirmed. If leprosy-associated inflammatory
reactions develop in patients being treated with dapsone and clofazimine,
it is still advisable to continue treatment with both drugs.
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