A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cialis Overdose, Contraindications and Information - Tadalafil
Cialis Overdose, Contraindications and Information - Tadalafil
OVERDOSE
Single doses up to 500 mg have been given to healthy subjects,
and multiple daily doses up to 100 mg have been given to patients. Adverse events
were similar to those seen at lower doses. In cases of overdose, standard supportive
measures should be adopted as required. Hemodialysis contributes negligibly
to tadalafil elimination.
CONTRAINDICATIONS
Nitrates — Administration of CIALIS to patients who
are using any form of organic nitrate, either regularly and/or intermittently,
is contraindicated. In clinical pharmacology studies, tadalafil was shown to
potentiate the hypotensive effect of nitrates. This is thought to result from
the combined effects of nitrates and tadalafil on the nitric oxide/cGMP pathway
(see Pharmacodynamics, Effects on Blood Pressure when CIALIS is Administered
with Nitrates under CLINICAL PHARMACOLOGY).
Alpha Blockers — Administration of CIALIS to patients
taking any alpha-adrenergic antagonist other than 0.4 mg once-daily tamsulosin
is contraindicated. In a drug-drug interaction study, when tadalafil 20 mg was
administered to healthy subjects taking doxazosin (8 mg daily), there was a
significant augmentation of the blood-pressure-lowering effect of doxazosin
(see Drug Interactions under
PRECAUTIONS).
Hypersensitivity — CIALIS is contraindicated for patients
with a known hypersensitivity to tadalafil or any component of the tablet.
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