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Thorazine Pharmacology, Pharmacokinetics, Studies, Metabolism - Chlorpromazine

Thorazine Pharmacology, Pharmacokinetics, Studies, Metabolism - Chlorpromazine

CLINICAL PHARMACOLOGY

ACTIONS

The precise mechanism whereby the therapeutic effects of chlorpromazine are produced is not known. The principal pharmacological actions are psychotropic. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system—primarily at subcortical levels—as well as on multiple organ systems. Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.

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