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Chloromycetin Overdose, Contraindications and Information - Chloramphenicol

OVERDOSE

IMPORTANT CONSIDERATIONS IN PRESCRIBING INJECTABLE CHLORAMPHENICOL SODIUM SUCCINATE:

Chloramphenicol sodium succinate is intended for IV use only. It has been demonstrated to be ineffective when given intramuscularly.

Chloramphenicol sodium succinate must be hydrolyzed to its microbiologically active form and there is a big lag in achieving adequate blood levels compared with the base given IV. ‘The oral form of chloramphenicol is readily absorbed and adequate blood levels are achieved and maintained on the recommended dosage.
Patients started on IV chloramphenicol sodium succinate should be changed to the oral form as soon as practicable.

CONTRAINDICATIONS

Chloramphenicol is contraindicated in individuals with a history of previous hypersensitivity and/or toxic reaction to it.

It must not be used in the treatment of trivial infections or where it is not indicated, as in colds, influenza, infections of the throat; or as a prophylactic agent to prevent bacterial infection.

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