A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Noctec Warnings, Precautions, Pregnancy, Nursing, Abuse - Chloral Hydrate
Noctec Warnings, Precautions, Pregnancy, Nursing, Abuse - Chloral Hydrate
WARNINGS
Chloral hydrate may
be habit-forming. Long-term use of larger than the usual therapeutic
doses may result in psychic
and physical dependence;
therefore, caution must be exercised when administering the drug
to patients susceptible to drug
abuse. Sudden withdrawal
may result in delirium. Chloral hydrate may increase the rate
of metabolism of
concomitantly administered coumarin or coumarinrelated anticoagulants,
thus reducing their effectiveness. Upon withdrawal
of chloral hydrate,
the rate of metabolism
of the anticoagulant drug may decrease with a concomitant
rise in plasma levels
and with the possibility of a gradual increase of anticoagulant
effects (i.e., development of bleeding
tendency and hemorrhage). Patients on oral
anticoagulant
therapy who are also taking chloral
hydrate should have
close observation of prothrombin times.
PRECAUTIONS
General
Chloral hydrate has
been reported to precipitate
attacks of acute intermittent
porphyria and should be used with caution in susceptible
patients. Continued use of therapeutic
doses of chloral hydrate
has been shown to be without deleterious effect
on the heart. Large doses of chloral
hydrate, however, should not be used in patients with severe cardiac
disease (See CONTRAINDICATIONS).
Drug/ Laboratory Test Interactions
Chloral hydrate may
interfere with copper
sulfate tests for glycosuria
(suspected glycosuria
should be confirmed by a glucose
oxidase test
when the patient is
receiving chloral hydrate),
fluorometric tests for urine catecholamines (it is recommended that
the medication not
be administered for 48 hours preceding the test), or urinary
17-hydroxycorticosteroid determinations (when using the Reddy, Jenkins,
and Thorn procedure).
Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term studies in animals have not been performed.
Pregnancy Category C
Animal reproduction
studies have not been conducted with chloral
hydrate. Chloral hydrate
crosses the placental
barrier and chronic
use during pregnancy may cause
withdrawal symptoms
in the neonate. It is not known whether chloral hydrate can affect
reproduction capacity.
Chloral hydrate should
be given to a pregnant
woman only if clearly
needed.
Nursing Mothers
Chloral hydrate is
excreted in human milk,
use by nursing mothers
may cause sedation
in the infant.
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