A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Noctec Overdose, Contraindications and Information - Chloral Hydrate
Noctec Overdose, Contraindications and Information - Chloral Hydrate
OVERDOSE
The signs and symptoms of chloral
hydrate overdosage resemble
those of barbiturate overdosage and especially affect
the CNS and cardiovascular
system. They may include: hypothermia; pinpoint pupils; blood
pressure falls; comatose
state; slow, or rapid and shallow breathing. Gastric irritation
may result in vomiting
and even gastric necrosis.
If the patient survives,
icterus due to hepatic
damage and albuminuria
from renal irritation
may appear.
The toxic oral
dose of chloral
hydrate for adults is
approximately 10 g; however, death
has been reported from a dose
of 4 g and some patients have survived after taking as much as 30
g.
Accidental overdosage should be treated with gastric
lavage or by inducing
vomiting to empty the stomach. Supportive measures may be used.
Hemodialysis is reported to be effective in promoting the clearance
of trichloroethanol.
CONTRAINDICATIONS
Chloral hydrate is
contraindicated in patients with marked hepatic
or renal impairment
and in patients with severe cardiac
disease. Oral dosage forms of chloral
hydrate are contraindicated
in the presence of gastritis. Chloral hydrate
is also contraindicated in patients who have previously exhibited
an idiosyncrasy
or hypersensitivity
to the drug.
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