A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Velosef Side Effects, and Drug Interactions - Cephradine
Velosef Side Effects, and Drug Interactions - Cephradine
SIDE EFFECTS
As with other cephalosporins, untoward reactions are limited essentially
to gastrointestinal disturbances and, on occasion, to hypersensitivity
phenomena. The latter are more likely to occur in individuals who have
previously demonstrated hypersensitivity and those with a history of allergy,
asthma, hay fever, or urticaria.
The following adverse reactions have been reported following the use
of cephradine:
Gastrointestinal: Symptoms of pseudomembranous colitis can appear
during antibiotic treatment. Nausea and vomiting have been reported rarely.
Skin and Hypersensitivity Reactions: Mild urticaria or skin rash,
pruritus, and joint pains were reported by very few patients.
Hematologic: Mild, transient eosinophilia, leukopenia, and neutropenia
have been reported.
Liver: Transient mild rise of SGOT, SGPT, and total bilirubin
have been observed with no evidence of hepatocellular damage.
Renal: Transitory rises in BUN have been observed in some patients
treated with cephalosporins; their frequency increases in patients over
50 years old. In adults for whom serum creatinine determinations were
performed, the rise in BUN was not accompanied by a rise in serum creatinine.
Other: Other adverse reactions have included dizziness and tightness
in the chest and candidal vaginitis.
DRUG INTERACTIONS
When administered concurrently, the following drugs may interact with
cephalosporins:
Other Antibacterial Agents — Bacteriostats may interfere
with the bactericidal action of cephalosporins in acute infection; other
agents, e.g., aminoglycosides, colistin, polymyxins, vancomycin, may increase
the possibility of nephrotoxicity.
Diuretics (potent "loop diuretics," e.g., furosemide and
ethacrynic acid) — Enhanced possibility for renal toxicity.
Probenecid — Increased and prolonged blood levels of cephalosporins,
resulting in increased risk of nephrotoxicity.
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