A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Rocephin Side Effects, and Drug Interactions - Ceftriaxone
Rocephin Side Effects, and Drug Interactions - Ceftriaxone
SIDE EFFECTS
Rocephin is generally well tolerated. In
clinical trials, the
following adverse reactions, which were considered to be related
to Rocephin therapy or of uncertain etiology,
were observed:
Local Reactions: pain,
induration and tenderness
was 1% overall. Phlebitis was reported in <11% after IV
administration. The incidence of injection
site reaction
was 17% (3/17) after IV administration
of 350 mg/mL and 5% (1/20) after IM administration
of 250 mg/mL.
Hypersensitivity: rash (1.7%). Less frequently reported
(<1%) were pruritus,
fever or chills.
Hematologic: eosinophilia (6%), thrombocytosis
(5.1%) and leukopenia
(2.1%). Less frequently reported (<1%) were anemia,
hemolytic anemia, neutropenia,
lymphopenia, thrombocytopenia
and prolongation of the prothrombin
time.
Gastrointestinal: diarrhea
(2.7%). Less frequently reported (<1%) were nausea
or vomiting, and dysgeusia.
The onset of pseudomembranous colitis symptoms may occur during
or after antibacterial
treatment (see WARNINGS).
Hepatc: elevations of SGOT
(3.1%) or SGPT (3.3%).
Less frequently reported (<1%) were elevations of alkaline
phosphatase and
bilirubin.
Renal: elevations of the BUN
(1.2%). Less frequently reported (<1%) were elevations of creatinine
and the presence of casts in the urine.
Central Nervous System: headache
or dizziness were
reported occasionally (<1%).
Genitourinary: moniliasis
or vaginitis were
reported occasionally (<1%).
Miscellaneous: diaphoresis
and flushing were reported occasionally (<1%).
Other rarely observed reactions (<0.1%) include leukocytosis,
lymphocytosis, monocytosis, basophilia, a decrease in the colitis,
flatulence, dyspepsia,
palpitations and epistaxis.
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