A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cefizox Side Effects, and Drug Interactions - Ceftizoxime
Cefizox Side Effects, and Drug Interactions - Ceftizoxime
SIDE EFFECTS
Cefizox® (ceftizoxime for injection,
USP) is generally well tolerated.
The most frequent adverse reactions (greater than 1 % but less
than 5%) are:
Hypersensitivity: Rash, pruritus,
fever.
Hepatic: Transient elevation
in AST (SGOT), ALT
(SGPT), and alkaline phosphatase.
Hematologic: Transienteosinophilia, thrombocytosis.
Some individuals have developed a positive
Coombs test.
Local—Injection site: Burning, cellulitis,
phlebitis with IV
administration, pain, induration,
tenderness, paresthesia.
The less frequent adverse reactions (less than 1%) are:
Hypersensitivity: Numbness and anaphylaxis
have been reported rarely.
Hepatic: Elevation of bilirubin
has been reported rarely.
Renal: Transient elevations of BUN
and creatinine have
been occasionally observed with Cefizox.
Hematologic: Anemia, including hemolytic
anemia with occasional
fatal outcome, leukopenia,
neutropenia, and
thrombocytopenia
have been reported rarely.
Urogenital: Vaginitis has occurred rarely.
Gastrointestinal: Diarrhea; nausea
and vomiting have been
reported occasionally.
Symptoms of pseudomembranous colitis
can appear during or after antibiotic treatment (see WARNINGS).
In addition to the
adverse reactions listed above which have been observed in patients
treated with ceftizoxime, the following adverse reactions and altered
laboratory tests
have been reported for cephalosporin-class antibiotics:
Stevens-Johnson syndrome,
erythema multiforme,
toxic epidermal necrolysis,
serum-sickness like reaction,
toxic nephropathy,
aplastic anemia, hemorrhage,
prolonged prothrombin. Several cephalosporins have been implicated
in triggering seizures, particularly in patients with renal
impairment, when
the dosage was not reduced. (See DOSAGE
ANDADMINISTRATION.) If seizures associated with drug
therapy occur, the
drug should be discontinued.
Anticonvulsant therapy
can be given if clinically indicated.
DRUG INTERACTIONS
Although the occurrence has not been reported with Cefizox, nephrotoxicity
has been reported following concomitant
administration
of other cephalosporins and aminoglycosides.
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