A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Caffeine - Sodium Benzoate Indications, Dosage, Storage, Stability - Caffeine and Sodium Benzoate
Caffeine - Sodium Benzoate Indications, Dosage, Storage, Stability - Caffeine and Sodium Benzoate
INDICATIONS
Caffeine and Sodium Benzoate Injection has been used in conjunction
with supportive measure
to treat respiratory
depression associated
with overdosage with CNS
depressant drugs
(e. g., narcotic analgesics,
alcohol). However, because of questionable benefit
and transient action,
most authorities believe caffeine
and other analeptics should not be used in these conditions and
recommend other supportive therapy.
DOSAGE AND ADMINISTRATION
Caffeine and Sodium Benzoate Injection may be administered by intramuscular
or slow intravenous
injection.
Some clinicians suggest that when as a mild CNS
stimulant to overcome
fatigue, oral doses of
100-200 mg of anhydrous
caffeine are required.
One manufacturer recommends that citrated
caffeine be administered
orally in dosages of 65-325 mg
(about 32-162 mg of anhydrous
caffeine) 3 times daily. Another manufacturer recommends an oral
dosage of 250 mg
of anhydrous caffeine
in an extended-release formulation once daily, but warns that the
drug should not be administered less than 6 hours before retiring.
Analeptic use of caffeine
is strongly discouraged by most clinicians. However, the manufacturer
of Caffeine and Sodium Benzoate Injection recommends intramuscular,
or in emergency respiratory
failure, intravenous
injection of 500 mg of the
drug (about 250 mg
of anhydrous caffeine)
or a maximum single dose
of 1 gram (about 500 mg
of anhydrous caffeine)
for the treatment of respiratory
depression associated
with overdosage of CNS depressants,
including narcotic
analgesics and alcohol,
and with electric shock.
The usual dose is 0.5
g (7-½ grains) as frequently directed by the physician. The
maximum safe dose
is 0.5 g and the total dose
in 24 hours should rarely exceed 2.5 g.
Parenteral drug products
should be inspected visually for particulate matter prior to administration
whenever solution and
container permit.
HOW SUPPLIED
Caffeine and Sodium Benzoate Injection, USP is available in 2 mL
single-use (500 mg) vials in trays of 10 NDC 51079-784-11.
Store at controlled room
temperature between
15°-30° C( 59°-86° F).
CAUTION: Federal (U.S.A.) law
prohibits dispensing without prescription.
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