A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Targretin Online, Description, Chemistry, Ingredients - Bexarotene
Targretin Online, Description, Chemistry, Ingredients - Bexarotene
| Targretin ® capsules are a member of the retinoid
class of drugs that is associated with birth defects in humans. Targretin
® capsules also caused birth defects when administered orally to pregnant
rats. Targretin ® capsules must not be administered to a pregnant
woman. See CONTRAINDICATIONS. |
Targretin ® (bexarotene) is a member of a subclass of retinoids that
selectively activate retinoid X receptors (RXRs). These retinoid receptors
have biologic activity distinct from that of retinoic acid receptors (RARs).
Each soft gelatin capsule for oral administration contains 75 mg of bexarotene.
The chemical name is 4-[1-(5,6,7,8 -tetrahydro- 3,5,5,8,8-pentamethyl -2-naphthalenyl) ethenyl]
benzoic acid, and the structual formula is as follows:
Bexarotene is an off-white to white powder with a molecular weight of
348.48 and a molecular formula of C24H28O2.
It is insoluble in water and slightly soluble in vegetable oils and ethanol,
USP.
Each Targretin ® (bexarotene) capsule also contains the following inactive
ingredients: polyethylene glycol 400, NF, polysorbate 20, NF, povidone,
USP, and butylated hydroxyanisole, NF. The capsule shell contains gelatin,
NF, sorbitol special-glycerin blend, and titanium dioxide, USP.
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