Celestone Pharmacology, Pharmacokinetics, Studies, Metabolism - Betamethasone (Injectable Suspension)

Celestone Pharmacology, Pharmacokinetics, Studies, Metabolism - Betamethasone (Injectable Suspension)

CLINICAL PHARMACOLOGY

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Naturally occurring glucocorticoids (hydrocortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.

Betamethasone sodium phosphate, a soluble ester, provides prompt activity, while betamethasone acetate is only slightly soluble and affords sustained activity.

Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body’s immune responses to diverse stimuli.