A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Bacteriostatic Saline Pharmacology, Pharmacokinetics, Studies, Metabolism - Bacteriostatic NaCl
Bacteriostatic Saline Pharmacology, Pharmacokinetics, Studies, Metabolism - Bacteriostatic NaCl
CLINICAL PHARMACOLOGY
Sodium chloride in water dissociates to provide sodium (Na+) and chloride
(Cl-) ions. These ions are normal constituents of the body fluids (principally
extracellular) and are essential for maintaining electrolyte balance.
The distribution and excretion of sodium (Na+) and chloride (Cl-) are
largely under the control of the kidney which maintains a balance between
intake and output.
The small volume of fluid and amount of sodium chloride provided by Bacteriostatic
0.9% Sodium Chloride Injection, USP, when used only as a vehicle for parenteral
injection of drugs, is unlikely to exert a significant effect on fluid
and electrolyte balance except possibly in very small infants.
Water is an essential constituent of all body tissues and accounts for
approximately 70% of total body weight. Average normal adult daily requirement
ranges from two to three liters (1.0 to 1.5 liters each for insensible
water loss by perspiration and urine production).
Water balance is maintained by various regulatory mechanisms. Water distribution
depends primarily on the concentration of electrolytes in the body compartments
and sodium (Na+) plays a major role in maintaining physiologic equilibrium.
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