A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Trinalin Side Effects, and Drug Interactions - Azatadine and Pseudoephedrine
Trinalin Side Effects, and Drug Interactions - Azatadine and Pseudoephedrine
SIDE EFFECTS
The following adverse reactions are associated with antihistamine
and sympathomimetic drugs. (Those adverse reactions which occur most frequently
with the antihistamines are underlined.)
General: Urticaria; drug
rash; anaphylactic shock; photosensitivity; excessive perspiration; chills;
dryness of mouth, nose, and
throat.
Cardiovascular: Hypertension (see CONTRAINDICATIONS
and WARNINGS), hypotension,
arrhythmias and cardiovascular
collapse, headache, palpitations,
extrasystoles, tachycardia, angina.
Hematologic: Hemolytic anemia,
hypoplastic anemia, thrombocytopenia,
agranulocytosis.
Central Nervous System: Sedation, sleepiness, dizziness,
vertigo, tinnitus, acute labyrinthitis,
disturbed coordination, fatigue,
mydriasis, confusion, restlessness, excitation, nervousness, tension,
tremor, irritability, insomnia,
euphoria, paresthesias, blurred
vision, hysteria, neuritis,
convulsions, fear, anxiety,
hallucinations, CNS depression,
weakness, pallor.
Gastrointestinal: Epigastric distress, anorexia,
nausea, vomiting, diarrhea,
constipation, abdominal
cramps.
Genitourinary: Urinary frequency, urinary
retention, dysuria, early
menses.
Respiratory: Thickening of bronchial
secretions, tightness of chest and wheezing,
nasal stuffiness, respiratory
difficulty.
DRUG ABUSE AND DEPENDENCE
There is no information to indicate
that abuse or dependency occurs
with azatadine maleate. Pseudoephedrine, like other central
nervous system stimulants,
has been abused. At high doses,
subjects commonly experience an elevation
of mood, a sense of increased
energy and alertness, and decreased
appetite. Some individuals become anxious, irritable,
and loquacious. In addition to the marked euphoria,
the user experiences a sense
of markedly enhanced physical
strength and mental
capacity. With continued use, tolerance develops, the user increases the
dose, and toxic signs and symptoms
appear. Depression may follow rapid withdrawal.
DRUG INTERACTIONS
MAO inhibitors prolong and intensify the effects of antihistamines. Concomitant
use of antihistamines with alcohol,
tricyclic antidepressants, barbiturates, or other central
nervous system
depressants may have an additive effect.
When sympathomimetic
drugs are given to patients receiving monoamine oxidase inhibitors, hypertensive
reactions, including hypertensive
crises, may occur. The antihypertensive
effects of methyldopa, mecamylamine, reserpine, and veratrum alkaloids
may be reduced by sympathomimetics. Beta-adrenergic blocking agents may
also interact with sympathomimetics. Increased ectopic pacemaker activity
can occur when pseudoephedrine is used concomitantly with digitalis. Antacids
increase the rate of absorption
of pseudoephedrine, while kaolin
decreases it.
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