A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Atridox Side Effects, and Drug Interactions - Doxycycline
Atridox Side Effects, and Drug Interactions - Doxycycline
SIDE EFFECTS
In clinical trials involving a total of 1436 patients, adverse experiences
from all causalities were monitored across treatment groups.
In the Circulatory System category, 10 subjects (1.6%) in the ATRIDOXTM
group were reported as having "unspecified essential hypertension." Only
1 subject (0.2%) in the Vehicle group, and none in the Scaling and Root
Planing or Oral Hygiene groups were reported to have "unspecified essential
hypertension." In all cases, the event occurred anywhere from 13 to 134
days post treatment. There is no known association of oral administration
of doxycycline with essential hypertension.
Two patients in the polymer vehicle group and none in the ATRIDOXTM
group (0.2% for both groups combined) reported adverse events consistent
with a localized allergic response.
Sex, age, race and smoking status did not appear to be correlated with
adverse events.
The following table lists the incidence of treatment-emergent adverse
events from all-causalities, across all treatment groups, occurring in
³1% of the entire study population.
|
Body System
Verbatim Terms
|
Doxycycline
n= 609 |
Vehicle
n=413 |
OH
n= 204 |
SRP
n= 210 |
| Circulatory |
| High blood pressure |
1.6% |
0.2% |
0.0% |
0.0% |
| Digestive
|
| Gum discomfort, pain or soreness; loss of attachment; increased
pocket depth |
18.1% |
23.0% |
20.1% |
21.0% |
| Toothache, pressure sensitivity |
14.3% |
14.3% |
10.3% |
18.1% |
| Periodontal abscess, exudate, infection, drainage,extreme mobility,
suppuration |
9.9% |
10.9% |
10.3% |
8.6% |
| Thermal tooth sensitivity |
7.7% |
8.5% |
4.4% |
6.7% |
| Gum inflammation, swelling, sensitivity |
4.1% |
5.8% |
5.4% |
5.7% |
| Soft tissue erythema, sore mouth, unspecified pain |
4.3% |
5.3% |
2.7% |
6.2% |
| Indigestion, upset stomach, stomachache |
3.6% |
4.1% |
2.9% |
3.8% |
| Diarrhea |
3.3% |
2.4% |
1.0% |
1.0% |
| Tooth mobility, bone loss |
2.0% |
0.7% |
0.5% |
2.4% |
| Periapical abscess, lesion |
1.5% |
1.9% |
1.0% |
0.5% |
| Aphthous ulcer, canker sores |
0.7% |
1.7% |
1.0% |
1.4% |
| Fistula |
0.8% |
1.5% |
1.5% |
1.0% |
| Endodontic abscess, pulpitis |
1.5% |
1.5% |
0.0% |
0.5% |
| Jaw pain |
1.1% |
0.5% |
1.0% |
1.9% |
| Tooth loss |
0.8% |
1.5% |
1.5% |
0.0% |
| Bleeding gums |
1.0% |
0.7% |
0.0% |
2.4% |
| Genitourinary% |
| Premenstrual tension syndrome |
4.4% |
3.1% |
2.5% |
3.3% |
| lll- Defined Conditions |
| Headache |
27.3% |
28.1% |
23.5% |
23.8% |
| Cough |
3.6% |
6.1% |
2.9% |
2.4% |
| Sleeplessness |
3.4% |
1.5% |
2.0% |
2.9% |
| Body aches, soreness |
1.6% |
1.2% |
1.5% |
1.4% |
| Nausea and vomiting |
1.8% |
0.7% |
2.5% |
0.5% |
| Fever |
1.0% |
1.9% |
1.0% |
1.9% |
| Injury & Poisoning |
| Broken tooth |
5.1% |
4.1% |
4.9% |
5.7% |
| Mental |
| Tension headache |
1.8% |
0.7% |
0.0% |
1.0% |
| Musculoskeletal |
| Muscle aches |
6.4% |
4.6% |
4.9% |
3.3% |
| Backaches |
3.6% |
5.3% |
2.5% |
6.2% |
| Pain in arms or legs |
1.5% |
2.2% |
2.0% |
2.4% |
| Lower back pain |
1.6% |
1.7% |
0.5% |
2.9% |
| Neck pain |
1.3% |
1.7% |
1.0% |
1.9% |
| Shoulder pain |
1.0% |
1.0% |
1.5% |
1.0% |
| Nervous System |
| Ear infection |
1.6% |
1.9% |
2.0% |
0.0% |
| Respiratory |
| Common cold |
25.5% |
25.2% |
18.1% |
16.7% |
| Flu, respiratory |
6.1% |
9.0% |
3.9% |
6.7% |
| Stuffy head, post nasal drip, congestion |
5.6% |
7.7% |
2.9% |
4.8% |
| Sore throat |
5.7% |
6.5% |
2.0% |
3.3% |
| Sinus infection |
5.3% |
2.7% |
1.0% |
1.9% |
| Flu |
2.8% |
2.9% |
2.9% |
3.3% |
| Bronchitis |
2.3% |
1.9% |
1.5% |
1.0% |
| Allergies |
1.0% |
1.0% |
1.0% |
1.9% |
| Skin & Subcutaneous
Tissue |
| Skin infection or inflammation |
1.3% |
1.0% |
1.0% |
1.0% |
DRUG INTERACTIONS
No information provided.
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