A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Armour Thyroid Overdose, Contraindications and Information - Thyroid tablets
Armour Thyroid Overdose, Contraindications and Information - Thyroid tablets
OVERDOSE
Signs and Symptoms
Excessive doses of thyroid result in a hypermetabolic state
resembling in every respect the condition of endoge-nous origin. The condition
may be self-induced.
Treatment of Overdosage
Dosage should be reduced or therapy temporarily discontinued
if signs and symptoms of overdosage appear. Treatment may be reinstituted at
a lower dosage. In normal individuals, normal hypothalamic-pituitary-thyroid
axis function is restored in 6to 8 weeks after thyroid suppression.
Treatment of acute massive thyroid hormone overdosage is aimed
at reducing gastrointestinal absorption of the drugs and counteracting central
and peripheral effects, mainly those of increased sympathetic activity. Vomiting
may be induced initially if further gastrointestinal absorption can reasonably
be prevented and barring contraindications such as coma, convulsions, or loss
of the gagging reflex. Treatment is symptomatic and supportive. Oxygen may be
administered and ventilation maintained. Cardiac glycosides may be indicated
if congestive heart failure develops. Measures to control fever, hypoglycemia,
or fluid loss should be instituted if needed. Antiadrenergic agents, particularly
pro-pranolol, have been used advantageously in the treatment of increased sympathetic
activity. Propranolol may be administered intravenously at a dosage of 1 to
3 mg, over a 10-minute period or orally,80 to 160 mg/day, initially, especially
when no contraindications exist for its use.
Other adjunctive measures may include administration of cholestyramine
to interfere with thyroxine absorption, and glucocor-ticoids to inhibit conversion
of T4 to T3.
CONTRAINDICATIONS
Thyroid hormone preparations are generally contraindicated
in patients with diagnosed but as yet uncorrected adrenal cortical insufficiency,
untreated thyrotoxicosis, and apparent hypersensitivity to any of their active
or extraneous constituents. There is no well-documented evidence from the literature,
however, of true allergic or idiosyncratic reactions to thyroid hormone.
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