Apidra Online, Description, Chemistry, Ingredients - Insulin glulisine

Apidra Online, Description, Chemistry, Ingredients - Insulin glulisine

APIDRA™ Insulin glulisine (rDNA origin) injection

APIDRA™ (insulin glulisine [rDNA origin]) is a human insulin analog that is a rapid-acting, parenteral blood glucose lowering agent. Insulin glulisine is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli (K12). Insulin glulisine differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid. Chemically, it is 3^B-lysine-29^B-glutamic acid-human insulin, has the empirical formula C₂₅₈H₃₈₄N₆₄O₇₈S₆ and a molecular weight of 5823.

APIDRA is a sterile, aqueous, clear, and colorless solution. Each milliliter of APIDRA (insulin glulisine injection) contains 100 IU (3.49 mg) insulin glulisine, 3.15 mg m-cresol, 6 mg tromethamine, 5 mg sodium chloride, 0.01 mg polysorbate 20, and water for injection. APIDRA has a pH of approximately 7.3. The pH is adjusted by addition of aqueous solutions of hydrochloric acid and/or sodium hydroxide.