A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Rattlesnake Antivenin Online, Description, Chemistry, Ingredients - Antivenin (Crotalidae) Polyvalent
Rattlesnake Antivenin Online, Description, Chemistry, Ingredients - Antivenin (Crotalidae) Polyvalent
DESCRIPTION
Important
Pit viper bites may cause
severe tissue damage
or fatal envenomation,
or both. The physician
responsible for treatment
of an envenomated patient should be familiar with the contents of
this brochure and the pertinent medical literature concerning current
concepts of first-aid and general supportive therapy as presented
in the references listed at the end
of this pamphlet.
Composition
Antivenin (Crotalidae) Polyvalent, Wyeth, is a refined and concentrated
preparation of serum globulins
obtained by fractionating blood
from healthy horses immunized with the following venoms: Crotalus
adamanteus (Eastern diamond rattlesnake), C. atrox (Western diamond
rattlesnake), C. durissus terrificus (tropical rattlesnake, Cascabel),
and Bothrops atrox (“Fer-de-lance”). Phenol, 0.25%, and thimerosal,
0.005%, are added as preservatives. The product is standardized
by its ability to neutralize
the lethal action of
standard venoms by
intravenous injection
in mice.1 Dried from the frozen state, the lyophilized
serum has a moisture content
of less than 1 % and is soluble
on addition of the
diluent contained in
each package (Bacteriostatic Water for Injection, USP, with preservative:
0.001 % phenylmercuric nitrate).
Antivenin (Crotalidae) Polyvalent, Wyeth (hereinafter referred
to as Antivenin) contains protective
substances capable of neutralizing the toxic effects of venoms of
crotalids (pit vipers) native
to North, Central, and South America, including rattlesnakes (Crotalus,
Sistrurus); copperhead and cottonmouth moccasins (Agkistrodon),
including A. halys of Korea and Japan; the Fer-de-lance and other
species of Bothrops;
the tropical rattler
(Crotalus durissus and similar species); the Cantil (A. bilineatus);
and bushmaster (Lachesis mutus) of South and Central America.
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