A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Paregoric Side Effects, and Drug Interactions - Anhydrous Morphine
Paregoric Side Effects, and Drug Interactions - Anhydrous Morphine
SIDE EFFECTS
The most frequent adverse reactions include lightheadedness, dizziness,
sedation, nausea, and vomiting.
These effects seem to be more prominent in ambulatory than in nonambulatory
patients, and some of these adverse reactions may be alleviated if the
patient lies down.
Other adverse reactions include euphoria,
dysphoria, constipation,
and pruritus.
DRUG ABUSE AND DEPENDENCE
Controlled Substance:
Paregoric is a Schedule III narcotic.
Dependence:
Morphine can produce drug dependence
and therefore has the potential for being abused. Patients receiving therapeutic
dosage regimens of 10 mg every
4 hours for 1 to 2 weeks have exhibited mild withdrawal
symptoms. Development of the dependent state
is recognizable by an increased tolerance to the analgesic
effect and the appearance
of purposive phenomena (complaints, pleas, demands, or manipulative actions)
shortly before the time of the
next scheduled dose. A patient
in withdrawal should be
treated in a hospital environment. Usually, it is necessary only to provide
supportive care with administration of a tranquilizer
to suppress anxiety. Severe symptoms of withdrawal may require administration
of a replacement narcotic.
DRUG INTERACTIONS
Morphine in combination with other narcotic
analgesics, general anesthetics, phenothiazines, tranquilizers, sedative/hypnotics
or other CNS depressants (including
alcohol) has additive depressant
effects, and the patient should
be so advised. When such combination therapy
is contemplated, the dosage of one or both agents should be reduced.
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