A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Aclovate Pharmacology, Pharmacokinetics, Studies, Metabolism - Alclometasone Dipropionate
Aclovate Pharmacology, Pharmacokinetics, Studies, Metabolism - Alclometasone Dipropionate
CLINICAL PHARMACOLOGY
Like other topical corticosteroids, alclometasone dipropionate has anti-inflammatory,
antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory
activity of the topical steroids, in general, is unclear. However, corticosteroids
are thought to act by the induction of phospholipase A2 inhibitory
proteins, collectively called lipocortins. It is postulated that these
proteins control the biosynthesis of potent mediators of inflammation
such as prostaglandins and leukotrienes by inhibiting the release of their
common precursor, arachidonic acid. Arachidonic acid is released from
membrane phospholipids by phospholipase A2 .
Pharmacokinetics
The extent of percutaneous absorption of topical corticosteroids is determined
by many factors, including the vehicle and the integrity of the epidermal
barrier. Occlusive dressings with hydrocortisone for up to 24 hours have
not been demonstrated to increase penetration; however, occlusion of hydrocortisone
for 96 hours markedly enhances penetration. Topical corticosteroids can
be absorbed from normal intact skin. Inflammation and/or other disease
processes in the skin may increase percutaneous absorption. A study utilizing
a radiolabeled alclometasone dipropionate ointment formulation was performed
to measure systemic absorption and excretion. Results indicated that approximately
3% of the steroid was absorbed during 8 hours of contact with intact skin
of normal volunteers.
Studies performed with ACLOVATE Cream and Ointment indicate that these
products are in the low to medium range of potency as compared with other
topical corticosteroids.
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