A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Aciphex Online, Description, Chemistry, Ingredients - Rabeprazole Sodium
Aciphex Online, Description, Chemistry, Ingredients - Rabeprazole Sodium
DESCRIPTION
The active ingredient in ACIPHEX® Delayed-Release Tablets
is rabeprazole sodium, a substituted benzimidazole that inhibits gastric acid
secretion. Rabeprazole sodium is known chemically as 2-[[[4-(3-methoxypropoxy) -3-methyl-2-pyridinyl]-methyl]sulfinyl] -1H–benzimidazole
sodium salt. It has an empirical formula of C18H20N3NaO3S
and a molecular weight of 381.43. Rabeprazole sodium is a white to slightly
yellowish-white solid. It is very soluble in water and methanol, freely soluble
in ethanol, chloroform and ethyl acetate and insoluble in ether and n-hexane.
The stability of rabeprazole sodium is a function of pH; it is rapidly degraded
in acid media, and is more stable under alkaline conditions. The structural
formula is:
RABEPRAZOLE SODIUM
ACIPHEX® is available for oral administration as delayed-release,
enteric-coated tablets containing 20 mg of rabeprazole sodium. Inactive ingredients
are carnauba wax, crospovidone, diacetylated monoglycerides, ethylcellulose,
hydroxypropyl cellulose, hypromellose phthalate, magnesium stearate, mannitol,
sodium hydroxide, sodium stearyl fumarate, talc, titanium dioxide, and yellow
ferric oxide as a coloring agent.
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