Navelbine Overdose, Contraindications and Information - Vinorelbine Tartrate

Navelbine Overdose, Contraindications and Information - Vinorelbine Tartrate

OVERDOSE

There is no known antidote for overdoses of NAVELBINE. Overdoses involving quantities up to 10 times the recommended dose (30 mg/m²) have been reported. The toxicities described were consistent with those listed in the ADVERSE REACTIONS section including paralytic ileus, stomatitis, and esophagitis. Bone marrow aplasia, sepsis, and paresis have also been reported. Fatalities have occurred following overdose of NAVELBINE. If overdosage occurs, general supportive measures together with appropriate blood transfusions, growth factors, and antibiotics should be instituted as deemed necessary by the physician.

CONTRAINDICATIONS

Administration of NAVELBINE is contraindicated in patients with pretreatment granulocyte counts <1,000 cells/mm³ (see WARNINGS).