A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Unasyn Online, Description, Chemistry, Ingredients - Ampicillin and Sulbactam
Unasyn Online, Description, Chemistry, Ingredients - Ampicillin and Sulbactam
DESCRIPTION
UNASYN is an injectable antibacterial combination consisting of the semisynthetic
antibiotic ampicillin sodium and the beta-lactamase inhibitor sulbactam sodium
for intravenous and intramuscular administration.
Ampicillin sodium is derived from the penicillin nucleus,6-aminopenicillanic
acid. Chemically, it is monosodium (2S, 5R, 6R)-6-[(R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
and has a molecular weight of 371.39. Its chemical formula is C 16 H
18 N 3 NaO 4 S.
Sulbactam sodium is a derivative of the basic penicillin nucleus. Chemically,
sulbactam sodium is sodium penicillinate sulfone; sodium (2S, 5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
4,4-dioxide. Its chemical formula is C 8 H 10 NNaO 5
S with a molecular weight of 255.22.
UNASYN, ampicillin sodium/sulbactam sodium parenteral combination, is available
as a white to off-white dry powder for reconstitution. UNASYN dry powder is
freely soluble in aqueous diluents to yield pale yellow to yellow solutions
containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin
per mL and 125 mg sulbactam per mL. The pH of the solutions is between 8.0 and
10.0.
Dilute solutions (up to 30 mg ampicillin and 15 mg sulbactam per mL) are essentially
colorless to pale yellow. The pH of dilute solutions remains the same.
1.5 g of UNASYN (1 g ampicillin as the sodium salt plus 0.5 g sulbactam as
the sodium salt) parenteral contains approximately 115 mg (5 mEq) of sodium.
3 g of UNASYN (2 g ampicillin as the sodium salt plus 1 g sulbactam as the
sodium salt) parenteral contains approximately 230 mg (10 mEq) of sodium.
top
