A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tao Warnings, Precautions, Pregnancy, Nursing, Abuse - Troleandomycin
Tao Warnings, Precautions, Pregnancy, Nursing, Abuse - Troleandomycin
WARNINGS
Usage in Pregnancy: Safety for use in pregnancy has not been established.
The administration of troleandomycin has been associated with an allergic type
of cholestatic hepatitis. Some patients receiving troleandomycin for more than
two weeks or in repeated courses have shown jaundice accompanied by right upper
quadrant pain, fever, nausea, vomiting, eosinophilia, and leukocytosis. These
changes have been reversible on discontinuance of the drug. Liver function tests
should be monitored in patients on such dosage, and the drug discontinued if
abnormalities develop. Reports in the literature have suggested that the concurrent
use of ergotamine-containing drugs and troleandomycin may induce ischemic reactions.
Therefore, the concurrent use of ergotamine-containing drugs and troleandomycin
should be avoided. Troleandomycin should be administered with caution to patients
concurrently receiving estrogen containing oral contraceptives.
Studies in chronic asthmatic patients have suggested that the concurrent use
of theophylline and troleandomycin may result in elevated serum concentrations
of theophylline. Therefore, it is recommended that patients receiving such concurrent
therapy be observed for signs of theophylline toxicity, and that therapy be
appropriately modified if such signs develop.
PRECAUTIONS
Troleandomycin is principally excreted by the liver.
Caution should be exercised in administering the antibiotic to patients with
impaired hepatic function.
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