A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Syprine Side Effects, and Drug Interactions - Trientine
Syprine Side Effects, and Drug Interactions - Trientine
SIDE EFFECTS
Clinical experience with SPYRINE has been limited. The following adverse reactions
have been reported in a clinical study in patients with Wilson's disease who
were on therapy with trientine hydrochloride: iron deficiency, systemic lupus
erythematosus (see CLINICAL PHARMACOLOGY). In addition, the following adverse
reactions have been reported in marketed use: dystonia, muscular spasm, myasthenia
gravis.
SYPRINE is not indicated for treatment of biliary cirrhosis, but in one study
of 4 patients treated with trientine hydrochloride for primary biliary cirrhosis,
the following adverse reactions were reported: heartburn; epigastric pain and
tenderness; thickening, fissuring and flaking of the skin; hypochromic microcytic
anemia; acute gastritis; aphthoid ulcers; abdominal pain; melena; anorexia;
malaise; cramps; muscle pain; weakness; rhabdomyolysis. A causal relationship
of these reactions to drug therapy could not be rejected or established.
DRUG INTERACTIONS
In general, mineral supplements should not be given since they may block the
absorption of SYPRINE. However, iron deficiency may develop, especially in children
and menstruating or pregnant women, or as a result of the low copper diet recommended
for Wilson's disease. If necessary, iron may be given in short courses, but
since iron and SYPRINE each inhibit absorption of the other, two hours should
elapse between administration of SYPRINE and iron.
It is important that SYPRINE be taken on an empty stomach, at least one hour
before meals or two hours after meals and at least one hour apart from any other
drug, food, or milk. This permits maximum absorption and reduces the likelihood
of inactivation of the drug by metal binding in the gastrointestinal tract.
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