A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Transderm Scop Online, Description, Chemistry, Ingredients - Scopolamine
Transderm Scop Online, Description, Chemistry, Ingredients - Scopolamine
DESCRIPTION
The Transderm Scop (transdermal scopolamine) system is a circular flat patch
designed for continuous release of scopolamine following application to an area
of intact skin on the head, behind the ear. Each system contains 1.5 mg of scopolamine
base. Scopolamine is (alpha)-(hydroxymethyl) benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo
[3.3.1.0 2,4 ] non-7-yl ester. The empirical formula is C 17
H 21 NO 4.
Scopolamine is a viscous liquid that has a molecular weight of 303.35 and a
pKa of 7.55-7.81. The Transderm Scop system is a film 0.2 mm thick and 2.5 cm
2 , with four layers. Proceeding from the visible surface towards
the surface attached to the skin, these layers are: (1) a backing layer of tan-colored,
aluminized, polyester film; (2) a drug reservoir of scopolamine, light mineral
oil, and polyisobutylene; (3) a microporous polypropylene membrane that controls
the rate of delivery of scopolamine from the system to the skin surface; and
(4) an adhesive formulation of mineral oil, polyisobutylene, and scopolamine.
A protective peel strip of siliconized polyester, which covers the adhesive
layer, is removed before the system is used. The inactive components, light
mineral oil (12.4 mg) and polyisobutylene (11.4 mg), are not released from the
system.
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