A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tracrium Online, Description, Chemistry, Ingredients - Atracurium Besylate
Tracrium Online, Description, Chemistry, Ingredients - Atracurium Besylate
DESCRIPTION
TRACRIUM (atracurium besylate) is an intermediate-duration, nondepolarizing,
skeletal muscle relaxant
for intravenous
administration. Atracurium besylate is designated as 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-
dimethoxyphenyl) methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate.
It has a molecular weight
of 1243.51, and its molecular formula
is C65H82N2O18S2.
Atracurium besylate is a complex
molecule containing
four sites at which different stereochemical
configurations can occur. The symmetry
of the molecule, however, results in only ten, instead of sixteen,
possible different isomers. The manufacture of atracurium besylate
results in these isomers being produced in unequal amounts but with
a consistent ratio. Those molecules in which the methyl
group attached to the
quaternary nitrogen
projects on the opposite side
to the adjacent substituted-benzyl moiety
predominate by approximately 3:1.
TRACRIUM Injection is a sterile,
nonpyrogenic aqueous
solution. Each mL contains 10 mg
atracurium besylate. The pH
is adjusted to 3.25 to 3.65 with benzenesulfonic acid. The multiple-dose
vial contains 0.9% benzyl
alcohol added as a preservative. TRACRIUM slowly loses potency
with time at the rate of
approximately 6% per year
under refrigeration
(5° C). TRACRIUM Injection should be refrigerated at 2°
to 8° C (36° to 46° F) to preserve potency. Rate of
loss in potency
increases to approximately 5% per
month at 25° C (77° F). Upon removal from refrigeration
to room temperature
storage conditions (25° C/ 77° F), use TRACRIUM Injection
within 14 days, even if rerefrigerated.
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