Timentin Overdose, Contraindications and Information - Ticarcillin and Clavulanate

Timentin Overdose, Contraindications and Information - Ticarcillin and Clavulanate

OVERDOSE

As with other penicillins, neurotoxic reactions may arise when very high doses of Timentin are administered, especially in patients with impaired renal function. (See WARNINGS and ADVERSE REACTIONS Central nervous system. )

In case of overdosage, discontinue Timentin , treat symptomatically, and institute supportive measures as required. Ticarcillin may be removed from circulation by hemodialysis. The molecular weight, degree of protein binding, and pharmacokinetic profile of clavulanic acid together with information from a single patient with renal insufficiency all suggest that this compound may also be removed by hemodialysis.

Timentin is contraindicated in patients with a history of hypersensitivity reactions to any of the penicillins.