Timentin Side Effects, and Drug Interactions - Ticarcillin and Clavulanate

Timentin Side Effects, and Drug Interactions - Ticarcillin and Clavulanate

SIDE EFFECTS

As with other penicillins, the following adverse reactions may occur:

Hypersensitivity reactions:   skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson Syndrome and anaphylactic reactions

Central nervous system:   headache, giddiness, neuromuscular hyperirritability, or convulsive seizures

Gastrointestinal disturbances:   disturbances of taste and smell, stomatitis, flatulence, nausea, vomiting and diarrhea, epigastric pain, and pseudomembranous colitis have been reported. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. (See WARNINGS.)

Hemic and lymphatic systems:   thrombocytopenia, leukopenia, neutropenia, eosinophilia, reduction of hemoglobin or hematocrit, and prolongation of prothrombin time and bleeding time

Abnormalities of hepatic and renal function tests:   elevation of serum aspartate aminotransferase (SGOT), serum alanine aminotransferase (SGPT), serum alkaline phosphatase, serum LDH, serum bilirubin. There have been reports of transient hepatitis and cholestatic jaundice as with some other penicillins and some cephalosporins. Elevation of serum creatinine and/or BUN, hypernatremia, reduction in serum potassium and uric acid

Local reactions:   pain, burning, swelling, and induration at the injection site and thrombophlebitis with intravenous administration

Available safety data for pediatric patients treated with Timentin demonstrate a similar adverse event profile to that observed in adult patients.

DRUG ABUSE AND DEPENDENCE

Neither Timentin abuse nor Timentin dependence has been reported.

As with other penicillins, the mixing of Timentin with an aminoglycoside in solutions for parenteral administration can result in substantial inactivation of the aminoglycoside.

Probenecid interferes with the renal tubular secretion of ticarcillin, thereby increasing serum concentrations and prolonging serum half-life of the antibiotic.

High urine concentrations of ticarcillin may produce false-positive protein reactions (pseudoproteinuria) with the following methods: sulfosalicylic acid and boiling test, acetic acid test, biuret reaction and nitric acid test. The bromphenol blue (Multi-stix®) reagent strip test has been reported to be reliable.

The presence of clavulanic acid in Timentin may cause a nonspecific binding of IgG and albumin by red cell membranes leading to a false-positive Coombs test.