A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Timentin Online, Description, Chemistry, Ingredients - Ticarcillin and Clavulanate
Timentin Online, Description, Chemistry, Ingredients - Ticarcillin and Clavulanate
DESCRIPTION
Timentin is a sterile injectable antibacterial combination consisting
of the semisynthetic antibiotic, ticarcillin disodium, and the (beta)-lactamase
inhibitor, clavulanate potassium (the potassium salt of clavulanic acid), for
intravenous administration. Ticarcillin is derived from the basic penicillin
nucleus, 6-amino-penicillanic acid.
Chemically, ticarcillin disodium is N -(2-Carboxy-3,3-dimethyl -7-oxo-4-thia-1-azabicyclo[3.2.0] hept-6-yl)-3-thio-
phenemalonamic acid disodium salt.
Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus
. It is a (beta)-lactam structurally related to the penicillins and possesses
the ability to inactivate a wide variety of (beta)-lactamases by blocking the
active sites of these enzymes. Clavulanic acid is particularly active against
the clinically important plasmid-mediated (beta)-lactamases frequently responsible
for transferred drug resistance to penicillins and cephalosporins.
Chemically, clavulanate potassium is potassium (Z)-(2 R ,5 R )-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-
azabicyclo[3.2.0] heptane-2-carboxylate.
Timentin is supplied as a white to pale yellow powder for reconstitution.
Timentin is very soluble in water, its solubility being greater than
600 mg/mL. The reconstituted solution is clear, colorless or pale yellow, having
a pH of 5.5 to 7.5.
For the Timentin 3.1 gram and 3.2 gram dosages, the theoretical sodium
content is 4.75 mEq (109 mg) per gram of Timentin . The theoretical potassium
content is 0.15 mEq (6 mg) and 0.3 mEq (11.9 mg) per gram of Timentin for
the 3.1 gram and 3.2 gram dosages, respectively.
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